Booth No. : A31

Presentation Representative : Masaru Tomita

Person in Charge of the Project : Shinji Fukuda

SFC BIO
Elucidation of the host defense mechanism by commensal microbes

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A wide variety of commensal microbes are colonized in our gut. They exert several physiological and pathological effects on our health via host-microbial crosstalk. It has been postulated that imbalance of the commensal microbes could be a risk factor for human disorders such as obesity, colonic cancer, as well as infectious diseases. Our recent research demonstrated that bifidobacteria, known as one of the ‘good’ commensal microbes, could prevent enterohemorrhagic E. coli O157:H7 infection through the up-regulation of gut epithelial barrier function. Further analysis showed that acetate produced by bifidobacteria is a key molecule for the inhibition of E. coli O157:H7 infection through the up-regulation of gut epithelial barrier function.

http://bio.sfc.keio.ac.jp/